PGRN Annual Meeting: Pushing Boundaries in PGx Discovery and Implementation

Monday, June 12 – Tuesday, June 13, 2023
St. Jude Children’s Research Hospital
Memphis, TN

Overview
The 2023 PGRN Annual Meeting is a 1.5-day, in-person event to be held at St Jude Children’s Research Hospital. The theme of this meeting is "Pushing Boundaries in Pharmacogenomics Discovery and Implementation". Day 1 will consist of scientific talks on both discovery science and clinical implantation of pharmacogenomics, as well as a poster session toward the end of the day. Day 2 will consist of two concurrent sessions: 1) a half-day workshop on how to use NIH All of Us dataset for pharmacogenomic research and 2) consecutive workshops on pharmacogenomics research resources (e.g., PharmGKB, PharmCAT, and PharmVar) followed by meetings of the Oncology and Psychiatry Interest Groups. The program will conclude at noon.

The mission of the Pharmacogenomics Global Research Network is to catalyze and lead research in precision medicine for the discovery and translation of genomic variation influencing therapeutic and adverse drug effects. To accomplish this, the PGRN aims to:
- Promote research and implementation in pharmacogenomics
- Provide a forum for collaboration, resource sharing, and education
- Foster awareness of the global importance of pharmacogenomics
Registration
- Early bird registration: Open from now until May 4, 2023 or until the first 100 slots are filled.
  
  Members: $150
  
  Non-members: $200
  
  Trainees: $75
- Regular registration: May 5, 2023 to June 2, 2023.
  
  Members: $175
  
  Non-members: $250 for nonmembers
  
  Trainees: $100
There is an additional $25 charge to attend the All of Us breakout session from 9:00 am – 12:00 pm on Tuesday, June 13.
Hotels

Host hotel: Caption by Hyatt

Additional downtown Memphis hotel options

Monday, June 12
Time	Event
7:00-8:00 am	Registration and breakfast
8:00-8:05 am	Opening Remarks
8:05-9:50 am	Session 1 Revolutionizing Precision Medicine with Advanced Genomic Analysis and Data Science TBD Marylyn Ritchie, PhD, University of Pennsylvania Understanding Kidney Function Is Really Important in Pharmacogenomics — So Why Do We Settle for Inadequate Measurements and Inappropriate Polygenic Risk Scores for Kidney Function? Nancy Cox, PhD, Vanderbilt University Medical Center Leveraging real-world clinico-genomics and data science to advance precision oncology James Zou, PhD, Stanford University Oral Abstract (15 mins)
9:50-10:10 am	Break
10:10-11:55 am	Session 2 Innovative Technologies for Functional Genomics and Single-Cell Profiling High Throughput Functional Annotation of Pharmacogene Variants Maitreya Dunahm, PhD, University of Washington In Search of New Targeted Therapies for Medulloblastoma. Tamra Werbowetski-Ogilive, University of Manitoba Powering Forward Genetics Using Multiplexed Single-Cell Sequencing Chun (Jimme) Ye, PhD Oral Abstract (15 mins)
12:00-1:00 pm	Lunch
1:00-2:45 pm	Session3 Transformative New Models for Understanding the Interplay of Genetics and Drug Response Validating the pharmacogenomics of doxorubicin-induced cardiotoxicity Paul Burridge, PhD, Northwestern University Assaying Drug Response in Highly Multiplexed Functional Transcriptomics Assays to Guide Personalized Cancer Therapy Christoph Merten, PhD, École Polytechnique Fédérale de Lausanne How does genetic variation act upon cellular phenotypes? Ralda Nehme, PhD, Broad Institute Oral Abstract (15 mins)
2:45-3:00 pm	Break
3:00-5:00 pm	Session 4 Overcoming Barriers to Pharmacogenomic and Genomic Medicine Implementation Polygenic Risk Score for Coronary Artery Diseases Across Multiple Populations: Challenge and Opportunity Catherine Tcheandjieu Gueliatcha, PhD, University of California San Francisco NHGRI’s Efforts to Advance Genomic Medicine Implementation Erin Ramos, PhD, MPH, National Human Genome Research Institute Demonstrating Clinical Utility of Pharmacogenetic Testing: A STRIPE Initiative Jai Patel, PharmD, Atrium Health Levine Cancer Institute Implementing PGx panel testing in Europe: results from the U-PGx PREPARE Study Jesse J. Swen, PharmD, PhD, Leiden University Medical Center
5:00-6:30 pm	Poster session (in person only), wine/cheese reception

Tuesday, June 13
8:00-8:45 am	Registration and breakfast
9:4509:00 am	Closing remarks/meeting room information
9:00 am-12:00 pm	Concurrent Sessions 9 am – 12 pm: All of Us half-day workshop 9am – 10:20 am: Pharmacogenomics Research Resources (PharmCAT, PharmGKB, PharmVar) 10:20 – 10:40 am: Break 10:40 am – 12:00 pm Oncology Special Interest Group 10:40 am – 12:00 pm Psychiatry Special Interest Group
12:00 pm	End of conference Boxed lunches for pickup in Marlo Thomas Atrium

Abstracts Guidelines and Information

The deadline to submit an abstract is April 14, 2023.

Format for abstracts are listed below:

Required Sections: Authors, Institutions, Background, Methods, Results, Conclusions
1 figure or table may be included
Word limit: 500 words

Conference Host

Jun J. Yang, PhD
Member and Vice Chair, Department of Pharmacy and Pharmaceutical Sciences
St. Jude Children’s Research Hospital

Speakers

Title TBD

Marylyn Ritchie, PhD
University of Pennsylvania

Understanding Kidney Function Is Really Important in Pharmacogenomics — So Why Do We Settle for Inadequate Measurements and Inappropriate Polygenic Risk Scores for Kidney Function?

Nancy Cox, PhD
Division Director, Division of Genetics, Department of Medicine
Vanderbilt University Medical Center

Leveraging real-world clinico-genomics and data science to advance precision oncology

James Zou, PhD
Assistant Professor of Biomedical Data Science and, by courtesy, of Computer Science and of Electrical Engineering
Stanford University

High throughput functional annotation of pharmacogene variants 

Maitreya Dunham, PhD
Professor of Genome Sciences
University of Washington

In search of new targeted therapies for medulloblastoma

Tamra Werbowetski-Ogilvie, BSc, PhD
Professor of Biochemistry and Medical Genetics
Max Rady College of Medicine
University of Manitoba

 Powering forward genetics using multiplexed single-cell sequencing

Chun (Jimmie) Ye, PhD
Associate Professor, Medicine
University of California, San Francisco

Validating the pharmacogenomics of doxorubicin-induced cardiotoxicity

Paul Burridge, PhD
Assistant Professor in Pharmacology
Feinberg School of Medicine
Northwestern University

Assaying drug response in highly multiplexed functional transcriptomics assays to guide personalized cancer therapy

Christoph Merten, PhD
Associate Professor, Laboratory for Biomedical Microfluidics
École Polytechnique Fédérale de Lausanne

How does genetic variation act upon cellular phenotypes?

Ralda Nehme, Ph.D.
Associate Director, Stem Cell Program
Broad Institute

Polygenic risk score for coronary artery diseases across multiple populations: challenge and opportunity

Catherine Tcheandjieu Gueliatcha, PhD
Assistant Investigator, Gladstone Institutes
Assistant Professor, Department of Epidemiology and Biostatistics
University of California, San Francisco

NHGRI’s Efforts to Advance Genomic Medicine Implementation

Erin M. Ramos, PhD, MPH
Deputy Director, Division of Genomic Medicine
National Human Genome Research Institut

Demonstrating Clinical Utility of Pharmacogenetic Testing: A STRIPE Initiative

Jai Patel, PharmD
Chair, Cancer Pharmacology & Pharmacogenomics
Atrium Health Levine Cancer Institute

Talk title: TBD

Jesse J. Swen, PharmD, PhD
Professor of Clinical Pharmacy
Section Chair of the Laboratory
Dept. Clinical Pharmacy & Toxicology
Leiden University Medical Center

PGRN Annual Meeting

Pushing boundaries in pharmacogenomics discovery and implementation

Overview

Registration

Hotels

Additional downtown Memphis hotel options

Abstracts Guidelines and Information

Conference Host

Speakers

Thank You