The annual Bringing Chemistry to Medicine symposium features thought leaders at the interface of chemical and biomedical sciences and is hosted by the St. Jude Department of Chemical Biology and Therapeutics and the St. Jude Comprehensive Cancer Center.
Videos by year
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Welcome and Introduction
Charles WM Roberts, MD, PhD
St. Jude Children's Research Hospital
Therapeutic Targeting of Chromatin Complexes in Cancer
Scott Armstrong, MD, PhD
Dana-Farber Cancer Institute
Etiology and Impact of Methylation Changes in Cancer
Bradley Bernstein, MD, PhD
Dana-Farber Cancer Institute
Transcriptional Hubs or Condensates?
Tanja Mittag, PhD
St. Jude Children's Research Hospital
Visualizing Drug-Binding Pockets in Transcription Factors
Fraydoon Rastinejad, PhD
University of Oxford
Modularized Molecule Making
Daniel Blair, PhD
University of Illinois at Urbana-Champaign
The Awesome Power of Synthetic Organic Chemistry in Drug Development
Ray Deshaies, PhD
AmGen, Inc.
Sequence-Based Design of Small Molecules Targeting RNA Structures to Manipulate and Study Disease Biology
Matt Disney, PhD
Scripps Research Institute (Florida)
Protein Dynamics at the Heart of New Cancer Drug Design Approaches
Dorothee Kern, PhD
Brandeis University
Regulation of Liver Energy Balance by Nutrient-sensing Nuclear Receptors
David Moore, PhD
University of California, Berkeley
A Chemist’s Foray into Translational Research
Peter Schultz, PhD
Scripps Research Institute (La Jolla) -
Histone Mutations and Disrupted Development in Pediatric High-Grade Glioma
Suzanne J. Baker, PhD
St. Jude Children's Research Hospital
Recorded: July 22, 2021
Recent Insights into Chromatin Transcription
Patrick Cramer, PhD
Max Planck Institute for Biophysical Chemistry
Recorded: July 22, 2021
NSD2 in Lymphoid Malignancy
Jonathan D. Licht, MD
University of Florida Cancer Center
Recorded: July 22, 2021
Structure and Function of Mammilian SWI/SNF Chromatin Remodeling Complexes in Human Cancer
Cigall Kadoch, PhD
Dana-Farber Cancer Institute
Harvard Medical School
Broad Institute of MIT and Harvard
Recorded: July 22, 2021
Three Possible Paths to Targeting Undruggable Transcripton Factors
William G. Kaelin Jr., MD
Harvard Medical School, Dana-Farber Cancer Institute
Recorded: July 22, 2021
Transcriptional Networks in Tumor-Infliltrating T-cells
Anjana Rao, PhD
LaJolla Institute for Immunology
Recorded: July 22, 2021
Personalization of Transcriptional Therapy with Drugs Targeting Nuclear Receptors
Mitchell A. Lazar, MD, PhD
University of Pennsylvania
Recorded: July 22, 2021
Rationalizing Anti-cancer Drug Responses Using Proteomics and Machine Learning: Towards Next Generation Precision Medicine
Pedro R. Cutillas, PhD
Barts Cancer Institute
Recorded: July 23, 2021
Predictors of response to cancer immunotherapy: Beyond Tumour Mutational Burden
Francesca Ciccarelli, PhD
King's College, London
Recorded July 23, 2021
Using Response Surface Models to Analyze Drug Combinations
Anang A. Shelat, PhD
St. Jude Children's Research Hospital
Recorded: July 23, 2021
Prediction of a Protein's Free Energy Surface with Validation Using Hydrogen/Deuterium Exchange
Tobin R. Sosnick, PhD
University of Chicago
Recorded: July 23, 2021
Computational Enzymology: The Structure, Function and Evolution of Enzymes
Professor Dame Janet Thornton
European Molecular Biology Laboratory
Recorded: July 23, 2021
Variation in GPCR Signaling: Implications for Drug Discovery
M. Madan Babu, PhD, FRSC
St. Jude Children's Research Hospital
Recorded: July 23, 2021
Chemical Control of Gene Expression
James E. Bradner MD
Novartis Institutes for Biomedical Research
Recorded: July 22, 2021
Discovery and Development of GPCR Allosteric Ligands: From Concept to Clinic
Craig W. Lindsley, PhD
Vanderbilt University
Recorded: July 23, 2021
Design, Syntheses and Studies of New Antibiotics
Marvin J. Miller, PhD
University of Notre Dame
Recorded: July 23, 2021 -
Chromatin Remodeler Mutations in Cancer: Mechanisms and Therapeutic Vulnerabilities
Charles Roberts, MD, PhD
St. Jude Children's Research Hospital
Recorded Sept. 24, 2020
Allosteric Antagonists of Methyl-lysine Reader Domain Interactions with DNA/RNA
Stephen Frye, PhD
University of North Carolina, Chapel Hill
Recorded Sept. 24, 2020
Painting Chromatin with Synthetic Protein Chemistry
Tom Muir, PhD
Princeton University
Recorded Sept. 24, 2020
Transcriptional Enhancers and Emergence of Form and Function During Development and Evolution
Joanna Wysocka, PhD
Stanford University
Recorded Sept. 24, 2020
Chemical Control of Gene Expression
Aseem Ansari, PhD
St. Jude Children's Research Hospital
Recorded Sept. 24, 2020
Writing the Rules for Targeting Dynamic Transcriptional Coactivators
Anna Mapp, PhD
University of Michigan
Recorded Sept. 24, 2020
Systematic Targeting of Transcription Factor-Coactivator Protein-Protein Interactions
Dr. Paramjit (Bobby) Arora
New York University
Recorded Sept. 24, 2020
Targeted Protein Degradation - A New Therapeutic Strategy
Nathanael Gray, PhD
Stanford University
Recorded Sept. 24, 2020
Attenuating Oncogenic Transcription with Small Molecules
Angela Koehler, PhD
Massachusetts Institute of Technology
Recorded Sept. 25, 2020
Chemical Transcription Modulators of Promiscuous Xenobiotic Receptors
Taosheng Chen, PhD, PMP
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020
Targeted Protein Degradation Platform
Zoran Rankovic, PhD
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020
Nuclear Condensates in Gene Regulation, Disease Pathology and Drug Partitioning
Rick Young, PhD
Massachusetts Institute of Technology
Recorded Sept. 24, 2020
Bromodomain-Selective BETi as Pediatric Anticancer Agents
Anang Shelat, PhD
Philip Potter, PhD
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020
Bridge Over Troubled Water Networks – Binding and Garfunkel
Marcus Fischer, PhD
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020
Network Models in Biology: From Molecular Machinery to Chromosomal Dynamics, to Systems Pharmacology
Ivet Bahar, PhD
University of Pittsburgh
Recorded Sept. 25, 2020
History and Future of Thalidomide Analogs in Human Health
Phil Chamberlain, PhD
Neomorph, Inc.
Recorded Sept. 25, 2020
Videos by Topic
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Histone Mutations and Disrupted Development in Pediatric High-Grade Glioma
Suzanne J. Baker, PhD
St. Jude Children's Research Hospital
Recorded: July 22, 2021
Recent Insights into Chromatin Transcription
Patrick Cramer, PhD
Max Planck Institute for Biophysical Chemistry
Recorded: July 22, 2021
NSD2 in Lymphoid Malignancy
Jonathan D. Licht, MD
University of Florida Cancer Center
Recorded: July 22, 2021
Structure and Function of Mammilian SWI/SNF Chromatin Remodeling Complexes in Human Cancer
Cigall Kadoch, PhD
Dana-Farber Cancer Institute
Harvard Medical School
Broad Institute of MIT and Harvard
Recorded: July 22, 2021
Chromatin Remodeler Mutations in Cancer: Mechanisms and Therapeutic Vulnerabilities
Charles Roberts, MD, PhD
St. Jude Children's Research Hospital
Recorded Sept. 24, 2020
Allosteric Antagonists of Methyl-lysine Reader Domain Interactions with DNA/RNA
Stephen Frye, PhD
University of North Carolina, Chapel Hill
Recorded Sept. 24, 2020
Painting Chromatin with Synthetic Protein Chemistry
Tom Muir, PhD
Princeton University
Recorded Sept. 24, 2020
Transcriptional Enhancers and Emergence of Form and Function During Development and Evolution
Joanna Wysocka, PhD
Stanford University
Recorded Sept. 24, 2020 -
Three Possible Paths to Targeting Undruggable Transcripton Factors
William G. Kaelin Jr., MD
Harvard Medical School, Dana-Farber Cancer Institute
Recorded: July 22, 2021
Transcriptional Networks in Tumor-Infliltrating T-cells
Anjana Rao, PhD
LaJolla Institute for Immunology
Recorded: July 22, 2021
Personalization of Transcriptional Therapy with Drugs Targeting Nuclear Receptors
Mitchell A. Lazar, MD, PhD
University of Pennsylvania
Recorded: July 22, 2021
Chemical Control of Gene Expression
Aseem Ansari, PhD
St. Jude Children's Research Hospital
Recorded Sept. 24, 2020
Writing the Rules for Targeting Dynamic Transcriptional Coactivators
Anna Mapp, PhD
University of Michigan
Recorded Sept. 24, 2020
Systematic Targeting of Transcription Factor-Coactivator Protein-Protein Interactions
Dr. Paramjit (Bobby) Arora
New York University
Recorded Sept. 24, 2020
Targeted Protein Degradation - A New Therapeutic Strategy
Nathanael Gray, PhD
Stanford University
Recorded Sept. 24, 2020
Attenuating Oncogenic Transcription with Small Molecules
Angela Koehler, PhD
Massachusetts Institute of Technology
Recorded Sept. 25, 2020
Chemical Transcription Modulators of Promiscuous Xenobiotic Receptors
Taosheng Chen, PhD, PMP
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020
Targeted Protein Degradation Platform
Zoran Rankovic, PhD
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020
Nuclear Condensates in Gene Regulation, Disease Pathology and Drug Partitioning
Rick Young, PhD
Massachusetts Institute of Technology
Recorded Sept. 24, 2020 -
Rationalizing Anti-cancer Drug Responses Using Proteomics and Machine Learning: Towards Next Generation Precision Medicine
Pedro R. Cutillas, PhD
Barts Cancer Institute
Recorded: July 23, 2021
Predictors of response to cancer immunotherapy: Beyond Tumour Mutational Burden
Francesca Ciccarelli, PhD
King's College, London
Recorded July 23, 2021
Using Response Surface Models to Analyze Drug Combinations
Anang A. Shelat, PhD
St. Jude Children's Research Hospital
Recorded: July 23, 2021
Prediction of a Protein's Free Energy Surface with Validation Using Hydrogen/Deuterium Exchange
Tobin R. Sosnick, PhD
University of Chicago
Recorded: July 23, 2021
Computational Enzymology: The Structure, Function and Evolution of Enzymes
Professor Dame Janet Thornton
European Molecular Biology Laboratory
Recorded: July 23, 2021
Variation in GPCR Signaling: Implications for Drug Discovery
M. Madan Babu, PhD, FRSC
St. Jude Children's Research Hospital
Recorded: July 23, 2021
Bromodomain-Selective BETi as Pediatric Anticancer Agents
Anang Shelat, PhD
Philip Potter, PhD
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020 -
Chemical Control of Gene Expression
James E. Bradner MD
Novartis Institutes for Biomedical Research
Recorded: July 22, 2021
Discovery and Development of GPCR Allosteric Ligands: From Concept to Clinic
Craig W. Lindsley, PhD
Vanderbilt University
Recorded: July 23, 2021
Design, Syntheses and Studies of New Antibiotics
Marvin J. Miller, PhD
University of Notre Dame
Recorded: July 23, 2021
Bridge Over Troubled Water Networks – Binding and Garfunkel
Marcus Fischer, PhD
St. Jude Children's Research Hospital
Recorded Sept. 25, 2020
Network Models in Biology: From Molecular Machinery to Chromosomal Dynamics, to Systems Pharmacology
Ivet Bahar, PhD
University of Pittsburgh
Recorded Sept. 25, 2020
History and Future of Thalidomide Analogs in Human Health
Phil Chamberlain, PhD
Neomorph, Inc.
Recorded Sept. 25, 2020
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