The CBT Symposium, held on September 25, brought together leading chemical biologists who are pioneering new synthetic approaches to investigate challenging questions in biology and molecular medicine.
Hosted by the Department of Chemical Biology & Therapeutics at St. Jude, the symposium offered a broad survey of major advances being made at the interface of chemistry and biology with presentations spanning structure-guided design of smart therapeutics, small molecule-based microarrays and novel chemical library designs, chemical dissection of cell differentiation and death programs, systems-level chemical informatics, and mechanistically informed clinical trials. Beyond present frontiers, the 2020 CBT Symposium explored emerging questions in biomedical sciences that can be uniquely answered by chemical and computational approaches.
Ivet Bahar
University of Pittsburgh
UP Drug Discovery Institute
Philip Chamberlain
James Chen
Stanford University
Tarun Kapoor
The Rockefeller University
Angela Koehler
MIT Biological Engineering
Jun Liu
Johns Hopkins University
Shaomeng Wang
University of Michigan
Scott C. Blanchard
Taosheng Chen
Marcus Fischer
Richard E. Lee
Tudor Moldoveanu
Philip M. Potter
Zoran Rankovic
Anang Shelat
| Time | Event |
|---|---|
| 8:45 - 9:00 am | Log in |
| 9:00 - 9:15 am | Dr. Aseem Ansari Opening Remarks |
| Session 1 | |
| 9:20 - 9:35 am | Dr. Scott Blanchard Bridging the Gap Between Biomolecular Structure and Function Through Single-Molecule Imaging |
| 9:40 - 9:55 am | Dr. Richard Lee Antibiotic Discovery at St. Jude |
| 10:00 - 10:25 am | Dr. Jun Liu Rapamycin-Inspired Macrocycles as Novel Chemical Probes and Drug Leads |
| 10:30 - 10:40 am | Break |
| 10:40 - 11:05 am | Dr. Angela Koehler Attenuating Oncogenic Transcription with Small Molecules |
| 11:10 - 11:25 am | Dr. Taosheng Chen Chemical Transcription Modulators of Promiscuous Xenobiotic Receptors |
| 11:30 - 11:55 am | Dr. Shaomeng Wang Induced Protein Degradation as a Therapeutic Strategy |
| 12:00 - 1:00 pm | Break |
| Session 2 | |
| 1:00 - 1:15 pm | Dr. Marcus Fischer Bridge Over Troubled Water Networks – Binding and Garfunkel |
| 1:20 - 1:45 pm | Dr. Ivet Bahar Network Models in Biology: From Molecular Machinery to Chromosomal Dynamics, to Systems Pharmacology |
| 1:50 - 2:05 pm | Break |
| 2:05 - 2:10 pm | Dr. Aseem Ansari Introduction of Dr. Tommaso Cupido |
| 2:10 - 2:15 pm | Dr. Tommaso Cupido Introduction of Dr. Tarun Kapoor and Dr. James Chen |
| 2:15 - 2:40 pm | Dr. Tarun Kapoor Chemical Biology of Drug Resistance |
| 2:45 - 3:10 pm | Dr. James Chen Targeting Colorectal Cancer with Aldehyde Dehydrogenase Inhibitors |
| 3:15 - 3:30 pm | Break |
| 3:30 - 3:45 pm | Dr. Zoran Rankovic Targeted Protein Degradation Platform |
| 3:50 - 4:15 pm | Dr. Phil Chamberlain History and Future of Thalidomide Analogs in Human Health |
| 4:20 - 4:55 pm | Dr. Anang Shelat and Dr. Phil Potter Bromodomain-Selective BETi as Pediatric Anticancer Agents |
| 5:00 - 5:15 pm | Dr. Tudor Moldoveanu Probing the Mechanism of Mitochondrial Apoptosis Initiation |
| 5:20 - 5:30 pm | Dr. Aseem Ansari Closing Remarks |
View the Partner Event
Held on Thursday, September 24, 2020
Transcription Therapy Symposium
The Transcription Therapy Symposium, held on Thursday, September 24, 2020, is a partner event under the overarching theme of Bringing Chemistry to Medicine. This preceding symposium covered scientific advances in chromatin and gene regulation, transcription-targeted therapeutics and more.
Learn more about the Transcription Therapy Symposium >>
Speakers
Aseem Ansari
St. Jude Children's Research Hospital
Paramjit (Bobby) Arora
New York University
Stephen Frye
University of North Carolina, Chapel Hill
Nathanael S. Gray
Stanford University
Anna Mapp
University of Michigan
Tom Muir
Princeton University
Charles W.M. Roberts
St. Jude Children's Research Hospital
Joanna Wysocka
Stanford University
Richard A. Young
Whitehead Institute
Massachusetts Institute of Technology