Melissa Hines, MD
Melissa Hines, MD

Melissa Hines, MD

Associate Member, St. Jude Faculty

  • Director, Histiocytosis and Immune Dysregulation Team

Departments

Divisions

Education

Fellow (Pediatric Critical Care Medicine) - North Carolina Children’s Hospital, University of North Carolina Hospitals, Chapel Hill, NC
Resident (General Pediatrics) - Le Bonheur Children’s Hospital, St Jude Children’s Research Hospital, University of Tennessee Health Science Center, Memphis, TN
MD - University of Tennessee Health Science Center, Memphis, TN
BS - Christian Brothers University, Memphis, TN

Honors & Awards

  • 2016  Amal Murarka Pediatric Teaching Award, University of North Carolina, Department of Pediatrics
  • 2010  Faculty Medal for Highest Academic Achievement, University of Tennessee, award given to medical school graduate with highest grade point average
  • 2009  Albright Armstrong Rice Scholarship, University of Tennessee, scholarship awarded based on academic merit
  • 2009  American Medical Association Scholars Fund, University of Tennessee, scholarship awarded based on academic merit
  • 2006 to 2008  Alumni Merit Scholarship, University of Tennessee, scholarship awarded based on academic merit

Research Interests

  • Hemophagocytic Lymphohistiocytosis (HLH)
  • Use of new therapies for HLH
  • Immune system dysregulation in pediatric hematology/oncology patients during critical illness including
    • Hyperinflammation
    • Thrombotic microangiopathy (TMA)
  • Use of cytokine inhibition and biologic therapies in pediatric critical illness
  • Immune-effector cell associated hemophagocytic syndrome (IEC-HS) and immune-effector cell associated cytokine release syndrome (CRS)

Contact Information

Melissa Hines, MD Critical Care Medicine MS 734, Room IA3305 St. Jude Children’s Research Hospital 262 Danny Thomas Place Memphis, TN 38105-3678

St. Jude Faculty List

Related Topics

Clinical Trials

Selected Publications

Böhm S, Wustrau K, Pachlopnik Schmid J, Prader S, Ahlmann M, Yacobovich J, Beier R, Speckmann C, Behnisch W, Ifversen M, Jordan M, Marsh R, Naumann-Bartsch N, Mauz-Körholz C, Hönig M, Schulz A, Malinowska I, Hines M, Nichols KE, Gil-Herrera J, Talano JA, Crooks B, Formankova R, Jorch N, Bakhtiar S, Kühnle I, Streiter M, Nathrath M, Russo A, Dürken M, Lang P, Lindemans C, Henter JI, Lehmberg K, Ehl S. Survival in primary hemophagocytic lymphohistiocytosis, 2016 to 2021: etoposide is better than its reputation. Blood Mar 7, 2024;143(10):872-881. doi: 10.1182/blood.2023022281. PubMed PMID: 37992218

Shakoory B, Geerlinks A, Wilejto M, Kernan K, Hines M, Romano M, Piskin D, Ravelli A, Sinha R, Aletaha D, Allen C, Bassiri H, Behrens EM, Carcillo J, Carl L, Chatham W, Cohen JI, Cron RQ, Drewniak E, Grom AA, Henderson LA, Horne A, Jordan MB, Nichols KE, Schulert G, Vastert S, Demirkaya E, Goldbach-Mansky R, de Benedetti F, Marsh RA, Canna SW. The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected haemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS). Ann Rheum Dis Oct 2023;82(10):1271-1285. doi: 10.1136/ard-2023-224123. Epub Jul 24, 2023. PubMed PMID: 37487610.

Shakoory B, Geerlinks A, Wilejto M, Kernan K, Hines M, Romano M, Piskin D, Ravelli A, Sinha R, Aletaha D, Allen C, Bassiri H, Behrens EM, Carcillo J, Carl L, Chatham W, Cohen JI, Cron RQ, Drewniak E, Grom AA, Henderson LA, Horne A, Jordan MB, Nichols KE, Schulert G, Vastert S, Demirkaya E, Goldbach-Mansky R, de Benedetti F, Marsh RA, Canna SW. The 2022 EULAR/ACR Points to Consider at the Early Stages of Diagnosis and Management of Suspected Haemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome (HLH/MAS). Arthritis Rheumatol Oct 2023;75(10):1714-1732. doi: 10.1002/art.42636. Epub Jul 24, 2023. PubMed PMID: 37486733

Flerlage T, Fan K, Qin Y, Agulnik A, Arias AV, Cheng C, Elbahlawan L, Ghafoor S, Hurley C, McArthur J, Morrison RR, Zhou Y, Park HJ, Carcillo JA, Hines MR. Mortality Risk Factors in Pediatric Onco-Critical Care Patients and Machine Learning Derived Early Onco-Critical Care Phenotypes in a Retrospective Cohort. Crit Care Explor Oct 2023;5(10):e0976. doi: 10.1097/CCE.0000000000000976. eCollection Oct 2023. PubMed PMID: 37780176; PubMed Central PMCID: PMC10538916

Hines MR, Knight TE, McNerney KO, Leick MB, Jain T, Ahmed S, Frigault MJ, Hill JA, Jain MD, Johnson WT, Lin Y, Mahadeo KM, Maron GM, Marsh RA, Neelapu SS, Nikiforow S, Ombrello AK, Shah NN, Talleur AC, Turicek D, Vatsayan A, Wong SW, Maus MV, Komanduri KV, Berliner N, Henter JI, Perales MA, Frey NV, Teachey DT, Frank MJ, Shah NN. Immune Effector Cell-Associated Hemophagocytic Lymphohistiocytosis-Like Syndrome. Transplant Cell Ther. 2023 Jul;29(7):438.e1-438.e16. doi: 10.1016/j.jtct.2023.03.006. Epub 2023 Mar 9. PubMed PMID: 36906275; PubMed Central PMCID: PMC10330221

Hu Z, Paul TK, Liu YC, McCarville ME, Hines M, Gheorghe G, Campbell PK. Malignancy in disguise: ALK-positive anaplastic large cell lymphoma with refractory hyperinflammation and CNS involvement. Pediatr Blood Cancer. 2023 May 17;:e30415. doi: 10.1002/pbc.30415. [Epub ahead of print] PubMed PMID: 37194628.

Aurora T, Joseph N, Bhoopalan SV, Caniza MA, Flerlage T, Ghafoor S, Hankins J, Hijano DR, Jesudas R, Kirkham J, Martinez H, Alfaro GM, Sharma A, Hines M. The successful use of eculizumab for treatment of thrombotic microangiopathy in pediatric acute SARSCoV2 infection and multisystem inflammatory syndrome in children. Haematologica  Oct 1, 2022;107(10):2517-2522. doi: 10.3324/haematol.2022.280603. PubMed PMID: 35615927; PubMed Central PMCID: PMC9521228.

Hines MR, von Bahr Greenwood T, Beutel G, Beutel K, Hays JA, Horne A, Janka G, Jordan MB, van Laar JAM, Lachmann G, Lehmberg K, Machowicz R, Miettunen P, La Rosée P, Shakoory B, Zinter MS, Henter JI. Consensus-Based Guidelines for the Recognition, Diagnosis, and Management of Hemophagocytic Lymphohistiocytosis in Critically Ill Children and Adults. Crit Care Med May 1, 2022;50(5):860-872. doi: 10.1097/CCM.0000000000005361. Epub Oct 5, 2021. PubMed PMID: 34605776.

Salek M, Oak N, Hines M, Maciaszek JL, Tatevossian R, Sharma A, Nichols KE, Campbell P. Development of BRAFV600E-positive acute myeloid leukemia in a patient on long-term dabrafenib for multisystem LCH. Blood Adv Apr 26, 2022;6(8):2681-2684. doi: 10.1182/bloodadvances.2021006229. PubMed PMID: 34996063; PubMed Central PMCID: PMC9043944.

Noi Sedu MC, Rusmawatiningtyas D, Makrufardi F, Kumara IF, Nurnaningsih, Hines M. Diagnostic challenges of hemophagocytic lymphohistiocytosis in child with multiorgan dysfunction in a low-resource setting: A case report. Ann Med Surg (Lond) Aug 2021;68:102630. doi: 10.1016/j.amsu.2021.102630. eCollection Aug 2021. PubMed PMID: 34401127; PubMed Central PMCID: PMC8347814.

Hines MR, Keenan C, Maron Alfaro G, Cheng C, Zhou Y, Sharma A, Hurley C, Nichols KE, Gottschalk S, Triplett BM, Talleur AC. Hemophagocytic lymphohistiocytosis-like toxicity (carHLH) after CD19-specific CAR T-cell therapy. Br J Haematol Aug 2021;194(4):701-707. doi: 10.1111/bjh.17662. Epub Jul 15, 2021. PubMed PMID: 34263927; PubMed Central PMCID: PMC8756350.

Hines MR, Nichols KE. HLH or sepsis: the truth is in the T cells. Blood Apr 29, 2021;137(17):2279-2280. doi: 10.1182/blood.2020010236. PubMed PMID: 33914076.

Ehl S, von Bahr Greenwood T, Bergsten E, Fischer A, Henter JI, Hines M, Lehmberg K, Janka G, Moshous D, Nichols KE. Is neutralization of IFN-γ sufficient to control inflammation in HLH? Pediatr Blood Cancer Mar 2021;68(3):e28886. doi: 10.1002/pbc.28886. Epub Jan 6, 2021. PubMed PMID: 33405364.

Blincoe A, Heeg M, Campbell PK, Hines M, Khojah A, Klein-Gitelman M, Talano JA, Speckmann C, Touzot F, Lankester A, Legger GE, Rivière JG, Garcia-Prat M, Alonso L, Putti MC, Lehmberg K, Maier S, El Chazli Y, Elmaksoud MA, Astigarraga I, Kurjane N, Bulina I, Kenina V, Bryceson Y, Rascon J, Lortie A, Goldstein G, Booth C, Worth A, Wassmer E, Schmitt EG, Warren JT, Bednarski JJ, Ali S, Chiang KY, Krueger J, Henry MM, Holland SM, Marsh RA, Ehl S, Haddad E. Neuroinflammatory Disease as an Isolated Manifestation of Hemophagocytic Lymphohistiocytosis. J Clin Immunol Aug 2020;40(6):901-916. doi: 10.1007/s10875-020-00814-6. Epub Jul 7, 2020. PubMed PMID: 32638196.

Nichols KE, Hines MR. NK cells: energized yet exhausted in adult HLH. Blood Jul 30, 2020;136(5):524-525. doi: 10.1182/blood.2020006097. PubMed PMID: 32730578

Nolan M, Oikonomou EK, Silversides CK, Hines MR, Thompson KA, Campbell BA, Amir E, Maxwell C, Thavendiranathan P. Impact of Cancer Therapy-Related Cardiac Dysfunction on Risk of Heart Failure in Pregnancy. JACC CardioOncol Jun 2020;2(2):153-162. doi: 10.1016/j.jaccao.2020.04.007. eCollection Jun 2020. PubMed PMID: 34396225; PubMed Central PMCID: PMC8352036.

Jordan MB, Allen CE, Greenberg J, Henry M, Hermiston ML, Kumar A, Hines M, Eckstein O, Ladisch S, Nichols KE, Rodriguez-Galindo C, Wistinghausen B, McClain KL. Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: Recommendations from the North American Consortium for Histiocytosis (NACHO). Pediatr Blood Cancer Nov 2019;66(11):e27929. doi: 10.1002/pbc.27929. Epub Jul 24, 2019. Review. PubMed PMID: 31339233; PubMed Central PMCID: PMC7340087.

Epperly R, Furman W, Hines M, Santiago T, Li Y, Madden R, Mamcarz E, Cervi D, Federico S, Triplett B, Talleur A. Secondary hemophagocytic syndrome after autologous hematopoietic cell transplant and immune therapy for neuroblastoma. Pediatr Blood Cancer Nov 2019;66(11):e27964. doi: 10.1002/pbc.27964. Epub Aug 12, 2019. PubMed PMID: 31407508.

La Rosée P, Horne A, Hines M, von Bahr Greenwood T, Machowicz R, Berliner N, Birndt S, Gil-Herrera J, Girschikofsky M, Jordan MB, Kumar A, van Laar JAM, Lachmann G, Nichols KE, Ramanan AV, Wang Y, Wang Z, Janka G, Henter JI. Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. Blood Jun 6, 2019;133(23):2465-2477. doi: 10.1182/blood.2018894618. Epub Apr 16, 2019. PubMed PMID: 30992265.

Chellapandian D, Hines MR, Zhang R, Jeng M, van den Bos C, Santa-María López V, Lehmberg K, Sieni E, Wang Y, Nakano T, Williams JA, Fustino NJ, Astigarraga I, Dunkel IJ, Abla O, van Halteren AGS, Pei D, Cheng C, Weitzman S, Sung L, Nichols KE. A multicenter study of patients with multisystem Langerhans cell histiocytosis who develop secondary hemophagocytic lymphohistiocytosis. Cancer Mar 15, 2019;125(6):963-971. doi: 10.1002/cncr.31893. Epub Dec 6, 2018. PubMed PMID: 30521100; PubMed Central PMCID: PMC6786263.

Ehl S, Astigarraga I, von Bahr Greenwood T, Hines M, Horne A, Ishii E, Janka G, Jordan MB, La Rosée P, Lehmberg K, Machowicz R, Nichols KE, Sieni E, Wang Z, Henter JI. Recommendations for the Use of Etoposide-Based Therapy and Bone Marrow Transplantation for the Treatment of HLH: Consensus Statements by the HLH Steering Committee of the Histiocyte Society. J Allergy Clin Immunol Pract Sep-Oct 2018;6(5):1508-1517. doi: 10.1016/j.jaip.2018.05.031. Epub Jul 4, 2018. Review. PubMed PMID: 30201097.

Hines MR, Nichols KE. Go with the flow: perforin and CD107a in HLH. Blood Jun 1, 2017;129(22):2954-2955. doi: 10.1182/blood-2017-04-773192. PubMed PMID: 28572174.

Hines MR, Mulrooney DA, Hudson MM, Ness KK, Green DM, Howard SC, Krasin M, Metzger ML. Pregnancy-associated cardiomyopathy in survivors of childhood cancer. J Cancer Surviv Feb 2016;10(1):113-21. doi: 10.1007/s11764-015-0457-8. Epub Jun 5, 2015. PubMed PMID: 26044903; PubMed Central PMCID: PMC4670599.

Hines-Thomas MR, Howard SC, Hudson MM, Krasin MJ, Kaste SC, Shulkin BL, Metzger ML. Utility of bone marrow biopsy at diagnosis in pediatric Hodgkin's lymphoma. Haematologica Oct 2010;95(10):1691-6. doi: 10.3324/haematol.2010.025072. Epub May 21, 2010. PubMed PMID: 20494933; PubMed Central PMCID: PMC2948094.

Zhao Y, Xiao J, Ueda M, Wang Y, Hines M, Nowak TS Jr, LeDoux MS. Glial elements contribute to stress-induced torsinA expression in the CNS and peripheral nervous system. Neuroscience Aug 13, 2008;155(2):439-53. doi: 10.1016/j.neuroscience.2008.04.053. Epub May 6, 2008. PubMed PMID: 18538941; PubMed Central PMCID: PMC2596935.

Hines-Thomas M, Kaste SC, Hudson MM, Howard SC, Liu WA, Wu J, Kun LE, Shulkin BL, Krasin MJ, Metzger ML. Comparison of gallium and PET scans at diagnosis and follow-up of pediatric patients with Hodgkin lymphoma. Pediatr Blood Cancer Aug 2008;51(2):198-203. doi: 10.1002/pbc.21574. PubMed PMID: 18428430.

Last update: March 2024

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