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Master autoimmune regulator gets by with a little help from its friends
06/27/2024
See how St. Jude researchers investigated Foxp3 function as a transcription cofactor in regulatory T cells in immune system activation and suppression.
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Study identifies high-risk type of childhood acute leukemia and potential treatment strategy
06/25/2024
Learn how St. Jude assembled an international cohort to better understand γδ T-ALL, a high-risk form of childhood cancer, and propose a new targeted treatment.
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Children genetically prone to cancer benefit from early standardized surveillance
06/20/2024
Discover new research that shows cancer surveillance deployed immediately after finding a genetic predisposition leads to earlier tumor detection & treatment.
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St. Jude scientists solve decades long mystery of NLRC5 sensor function in cell death and disease
06/14/2024
Learn about immunology research from the St. Jude laboratory of Thirumala-Devi Kanneganti, PhD, that revealed the function of the NLRC5 innate immune sensor.
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Novel insights into fluorescent ‘dark states’ illuminate ways forward for improved imaging
06/14/2024
See how fluorescent dark triplet states in single molecule FRET can be avoided with self-healing fluorophores.
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Age is just a number: Immune cell ‘epigenetic clock’ ticks independently of organism lifespan
06/12/2024
See how St. Jude researchers use epigenetic clock, DNA methylation and mouse model to demonstrate that T cell proliferation can stretch past organism lifespan and acute lymphoblastic leukemia T cells appear hundreds of years old.
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‘Goldilocks’ binding strength determines anti-cancer T-cell efficacy and fate
05/30/2024
Learn how progenitor exhausted T cells’ receptor binding strength to cancer antigens determines the anti-cancer response with implications for immunotherapy.
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Cell-targeting technology allows researchers to isolate neuronal subpopulations and link them to behavioral states
05/27/2024
See how neurology tool Conditional Viral Expression by Ribozyme Guided Degradation (ConVERGD) allows researchers to isolate subpopulations of cells with increased accuracy and ease
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Repurposed protease controls important signaling molecule-activating protein
05/22/2024
See how cryo-EM reveals iRhom2 acts as regulator of ADAM17 activity and controls activation of tumor necrosis factor and many growth factors by binding ADAM17 prodomain.
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Novel inhibitor insights offer pathway to preventing PXR-associated drug resistance
05/14/2024
See how novel pregnane X receptor inhibitors offer structural understanding behind activator and repressor activity, guiding future drug design research to combat drug resistance
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