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Finding Cures. Saving Children.
Cancer Center Members
Department of Anesthesiology
Research interests: pain management, anesthesia risks, palliative care
Department of Epidemiology & Cancer Control
Research interests: pediatric neuro-oncology and cancer survivorship
Cancer Center Administration
Richard A. Ashmun, PhDDepartment of Genetics & Tumor Cell Biology
Research interests: applications of flow cytometry and cell separation
Department of Oncology
Research interests: integration of palliative care practices in the care of children with cancer; including specific interests of symptom assessment and control and decision making at the end of life
Department of Pharmaceutical Sciences
Research interests: clinical pharmacology of tyrosine kinase inhibitors
Department of Developmental Neurobiology
Research interests: PTEN and key signaling pathways in brain tumors
Department of Immunology
Research interests: stress proteins, immune homeostasis, tumorigenesis
Department of Radiological Sciences
Research interests: information-guided and adaptive radiation delivery
Department of Immunology
Research interests: cytokine gene regulation in T-cell differentiation
Department of Biostatistics
Research interests: statistical design and analysis of clinical trials
Department of Biochemistry
Research interests: gene regulation by transcriptional coactivators
Department of Oncology
Research interests: biology and treatment of high-grade gliomas
Department of Oncology
Research interests: monitoring and cell therapy of childhood cancer
Department of Chemical Biology & Therapeutics
Research interests: small-molecule transcription factor drug discovery
Department of Biostatistics
Research interests: statistical methods in cancer genomics and genetics
Clinical Education & Training Office, Infectious Diseases
Research interests: pediatric infectious diseases
Department of Immunology
Research interests: cellular signaling in innate and adaptive immunity
Administration, Government Relations
Heather Conklin, PhDDepartment of Behavioral Medicine
Research interests: cognitive outcomes of childhood cancer treatment
Department of Immunology
Research interests: genetic disorders of B-cell development
Cell & Tissue Imaging Center
Cheryl Cox, PhDDepartment of Epidemiology & Cancer Control
Research interests: health promotion, early/late effects of treatment
Department of Molecular Pharmacology
Research interests: stem cell-mediated tumor-specific therapy
Department of Genetics & Tumor Cell Biology
Research interests: intracellular degradation in development and disease
Department of Oncology (BMT)
Stem cell and T-cell development; Cord blood transplant; Infections and immune reconstitution after bone marrow transplant
Department of Surgery
Research interests: angiogenesis inhibition for cancer therapy
Department of Oncology
Research interests: research in bone sarcomas and drug development
Department of Pathology
Research interests: the molecular pathology of acute leukemia
Department of Developmental Neurobiology
Research interests: retinal development and retinoblastoma
Department of Pathology
Research interests: pathologic/molecular classification of CNS tumors
Department of Structural Biology
Research interests: Molecular mechanisms of DNA replication
St. Jude Director, Department of Pharmaceutical Sciences
Research interests: pharmacogenomics of antileukemic agents in children
Department of Infectious Diseases
Research interests: HIV/AIDS and infections in children with cancer
Cell & Tissue Imaging Center
Naoaki Fujii, PhDDepartment of Chemical Biology & Therapeutics
Research interests: medicinal chemistry, chemical biology, PDZ domain
Department of Oncology
Research interests: new drug development, neuroblastoma, liver tumors
Department of Oncology
Research interests: novel treatments for children with brain tumors
Department of Pathology
Research interests: T-cell regulation, autoimmunity, lab medicine
Department of Developmental Neurobiology
Research interests: the cellular and molecular origins of brain tumors
Vector Development & Production Shared Resource
Daniel M. Green, MDDepartment of Epidemiology and Cancer Control
Research interests: Late effects of treatment for childhood cancer, particularly reproductive and cardiac late effects, and the treatment of Wilms tumor
Department of Immunology
Research interests: apoptosis, autophage and mitochondria
Academic Programs
Gerard Grosveld, PhDDepartment of Genetics & Tumor Cell Biology
Research interests: the role of chromosome translocations in cancer
Department of Chemical Biology & Therapeutics
Research interests: chemical biology and orphan disease drug discovery
Department of Infectious Diseases
Research interests: signal transduction of Toll-like and TNF receptors
Department of Radiological Sciences
Research interests: cerebral perfusion and white matter connectivity
Department of Genetics & Tumor Cell Biology
Research interests: ER quality control in development and disease
Department of Radiological Sciences
Research interests: MR physics - methods and device development
Department of Oncology
Research interests: leukemia and lymphoma, international outreach
Department of Oncology
Research interests: health outcomes after childhood cancer
Department of Biochemistry
Research interests: cytokine binding, signaling and cellular responses
Department of Oncology
Research Interests: novel therapies for leukemia/lymphoma, especially acute myeloid leukemia and lymphoblastic lymphoma
Department of Oncology
Research interests: childhood leukemias, developmental therapeutics
Department of Pathology
Research interests: childhood tumor diagnosis by molecular techniques
Department of Oncology
Research interests: palliative care, quality of life, quality of care
Department of Immunology
Research interests: mechanisms of host defense and inflammation
Department of Oncology
Research interests: DNA damage and repair, tumorigenesis, radiobiology
Department of Radiological Sciences
Research interests: skeletal toxicities in childhood cancer survivors
Department of Molecular Pharmacology
Research interests: role of the spindle checkpoint in tumorigenesis
Department of Molecular Pharmacology
Research interests: role of the spindle checkpoint in genome stability
Department of Epidemiology & Cancer Control
Research interests: cancer prevention and control in adults and children
Department of Behavioral Medicine
Research interests: men's and women's health in cancer survivorship
Department of Radiological Sciences
Research interests: developing local therapy strategies for sarcomas
Department of Structural Biology
Research interests: structural basis of tumor suppressor function
Department of Epidemiology and Cancer Control
Research interests: The neurocognitive outcomes and late effects of childhood cancer, as well as using biologic and psychosocial moderators/mediators of these effects to design interventions for deficits in attention, memory, and executive functions
Department of Radiological Sciences
Research interests: improving diagnosis and therapy of brain tumors
Department of Pathology
Research Interests: Mechanisms involved in mitochondrial clearance and links to hematopoietic malignancies
Department of Genetics & Tumor Cell Biology
Research interests: apoptosis, mitosis and RNA synthesis in tumors
Administration, Clinical Director and Executive Vice President
Wing H. Leung, MD, PhDDepartment of Oncology (BMT)
Research interests: NK cell and stem cell transplantation, late effects
Department of Radiological Sciences
Research interests: solid tumor imaging and contrast-enhanced sonography
Department of Immunology
Research Interests: T cell regulation, autoimmunity, and immunomodulation
Department of Oncology
Research interests: neuroblastoma therapy, Phase I trials in children
Department of Genetics & Tumor Cell Biology
Research interests: DNA damage responses in the nervous system
Department of Pathology
Research interests: embryonic blood and vascular development
Department of Radiological Sciences
Research interests: radiation-related CNS effects
Department of Oncology
Research interests: Hodgkin and non-Hodgkin lymphomas, leukemias, IOP
Department of Developmental Neurobiology
Research interests: control of neuronal death and differentiation
Department of Oncology
Research interests: neurologic morbidity related to childhood cancer
Department of Pathology
Research interests: molecular oncology and targeted therapies
Department of Pathology
Research interests: genomic profiling of acute leukemia
Department of Infectious Diseases
Research interests: control of inflammatory responses
Chief Information Officer, Information Sciences
Research interests: bioinformatics, high-throughput biotechnologies
Department of Oncology
Research interests: treatment of pediatric sarcomas and melanoma
Hartwell Center for Bioinformatics & Biotechnology
Kirsten K. Ness, PT, PhDDepartment of Epidemiology & Cancer Control
Research interests: functional limitations among cancer survivors
Department of Biochemistry
Research interests: mechanisms of erythroid differentiation
Department of Hematology
Research interests: genetic therapy of hematological diseases
Department of Molecular Pharmacology
Research interests: topoisomerases, repair of DNA double-strand breaks
Department of Biochemistry
Research interests: metabolic regulation of apoptosis; calcium homeostasis during apoptosis; metabolic regulation of ER stress
Department of Biochemistry
Research Interest: mechanisms of Hedgehog signal transduction in development and disease
Department of Radiological Sciences
Research interests: brain function of survivors of childhood diseases
Department of Genetics & Tumor Cell Biology
Research interests: development of the CNS and lymphatic vasculature
Department of Biostatistics
Research interests: Ph I-II designs, bioinformatics, survival analy
Department of Pathology
Research interests: pediatric acute leukemia, pediatric lymphoma
Department of Biochemistry
Research interests: regulation of cell death during hematopoiesis
Department of Biochemistry
Research interests: chromosome segregation, heterochromatin assembly
Department of Hematology
Research interests: gene therapy development for hemoglobin disorders
Department of Behavioral Medicine
Research interests: coping and adjustment in children with cancer
Research interests: immunoregulatory cell networks; prevention of graft-versus-host disease (GVHD); immune mechanisms of separation of GVT from GVHD
Philip M. Potter, PhDDepartment of Molecular Pharmacology
Research interests: anticancer drug hydrolysis by carboxylesterases
Department of Biostatistics
Research interests: develop statistical methods for genomics studies
Department of Oncology
Research interests: biology and treatment of childhood leukemia
Department of Oncology
Research interests: low grade gliomas as unique diseases; advancing study of pediatric brain tumors in developing countries through international collaboration, twinning, and telemedicine
Department of Pathology
Research interests: laboratory animal medicine
Department of Surgery
Research interests: surgical management of sarcomas and rare tumors
Department of Radiological Sciences
Research interests: white matter injury and neurocognitive functioning
Department of Pharmaceutical Sciences
Research interests: pharmacokinetics and genetics of leukemia therapy
Department of Oncology
Research interests: international outreach, hematological malignancies
Department of Immunology
Research interests: immunomodulation, regulatory T-cell function
Department of Epidemiology & Cancer Control
Research interests: pediatric cancer epidemiology and outcomes
Department of Infectious Diseases
Research interests: membrane phospholipid metabolism
Department of Genetics & Tumor Cell Biology
Research interests: genes and microRNAs in brain tumors
Department of Oncology
Research interests: treatment of acute myeloid leukemia
Department of Oncology
Research interests: clinical and biologic investigation of NHL and ALL
Department of Oncology
Research interests: novel therapeutics, neuroblastoma, research ethics
Department of Pharmaceutical Sciences
Research interests: mechanisms of human variation in drug response
Department of Pharmaceutical Sciences
Research interests: regulation and function of ABC transporters
Department of Structural Biology
Research interests: cellular regulation by ubiquitin-like proteins
Department of Radiological Sciences
Research interests: medical image computing
Department of Genetics & Tumor Cell Biology
Research interests: tumor suppressor-dependent signaling networks
Department of Radiological Sciences
Research interests: PET CT imaging and evaluation of pediatric tumors
Department of Developmental Neurobiology
Research interests: models of CNS disease, amphetamines and the CNS
Vice President for Scientific Operations
Scott E. Snyder, PhDDepartments of Radiological Sciences and Chemical Biology & Therapeutics
Research interests: design of radioactive drugs for medical imaging
Department of Developmental Neurobiology
Research interests: cell polarity in neuron precursor differentiation
Department of Hematology
Research interests: gene therapy and hematopoietic stem cell biology
Department of Genetics & Tumor Cell Biology
Research interests: pancreas and liver organogenesis in mammals
Department of Oncology
Research interests: soft tissue sarcomas of childhood
Department of Biostatistics
Research interests: clinical trials, robust methods, survival analysis
Department of Pharmaceutical Sciences
Research interests: pharmacology of anticancer drugs in children
Department of Developmental Neurobiology
Research interests: To understand the roles of catabolic pathways
Department of Chemical Biology & Therapeutics
Research interests: using zebrafish to study the development, maintenance, and function of the blood-brain barrier; model pediatric brain tumors; perform high-throughput small molecule screens
Department of Oncology
Research interests: Hematopoietic cell transplant for high risk leukemia; Use of alternative donors in patients lacking a fully matched sibling donor; Immune reconstitution following hematopoietic cell transplant
Department of Behavioral Medicine
Research interests: health behavior trials, tobacco control
Department of Immunology
Research interests: regulatory T cells and T-cell signaling
Department of Chemical Biology & Therapeutics
Research interests: pursing anti-tumor drug discovery projects with a focus on compounds that inhibit the spliceosome
Department of Structural Biology
Research interests: structural analysis of catalysis and DNA repair
Department of Oncology
Research interests: biology and therapeutics of pediatric leukemias
Department of Biostatistics
Research interests: design and analysis of preclinical and clinical trials
Department of Biostatistics
Research interests: sequential analysis and stochastic modeling
Department of Chemical Biology & Therapetics
Research Interests: developing novel anti-cancer small molecule agents to treat cancer and develop cancer targeting nanoparticles for cancer treatment and diagnosis
Department of Developmental Neurobiology
Research interests: synaptic and neuronal mechanisms of schizophrenia
Department of Biochemistry
Research interests: p53 function in tumor suppression and tumorigenesis
Department of Structural Biology
Research interests: protein NMR and structure-based drug discovery
Department of Developmental Neurobiology
Research interests: hair cell function and regeneration in mice
