Department of Tumor Cell Biology

Investigators in the Department of Tumor Cell Biology are driven to understand how oncogenes, tumor suppressors, and checkpoint monitors of cellular stress govern tumor initiation, progression, and responses to cancer therapy. Identifying key regulatory proteins, defining their mechanisms of action, and determining how they function within complex signaling networks continues to provide a better understanding of the fundamental processes controlling cell proliferation, apoptosis, cell migration, and metastasis. Emphasis is placed on mouse models of particular pediatric cancers, including medulloblastoma, atypical teratoid rhabdoid tumors, neuroblastoma, and acute lymphoblastic leukemia. All faculty members participate in interdepartmental Program Project Grants and basic science programs of the Comprehensive Cancer Center.